The orange, six-sided pill marked with the imprint M 8N has been recognized as Buprenorphine Hydrochloride and Naloxone Hydrochloride (Sublingual) in the strength of 8 mg (base) / 2 mg (base). This medication is provided by SpecGx LLC.
This combination of buprenorphine/naloxone is employed for treating Opioid Use Disorder and falls into the category of medications known as narcotic analgesic combinations.
The potential risks during pregnancy cannot be disregarded. Buprenorphine/naloxone with a composition of 8 mg (base) / 2 mg (base) is categorized as a Schedule 3 controlled substance as per the Controlled Substance Act (CSA).
How to use N8 LOGO Pill Orange Six-sided 11mm
Prior to commencing the consumption of the N8 LOGO Pill, an orange, six-sided pill measuring 11mm, it is advised to carefully review the Medication Guide provided by your pharmacist. This should be done both before you start taking the medication and each time you obtain a refill. If any queries arise, it is recommended to seek guidance from your doctor or pharmacist.
It’s important to note that there are various brands and formulations of this medication available. Since different products could contain varying amounts of buprenorphine and naloxone, altering brands or dosage forms without consulting your doctor or pharmacist should be avoided.
During your treatment maintenance period, as directed by your doctor, typically on a daily basis, you should utilize this medication. Place it beneath your tongue and allow it to dissolve fully for a duration of 5 to 10 minutes.
If you have been prescribed multiple tablets daily, they can be placed under your tongue simultaneously or in groups of two. It’s crucial not to swallow or chew the medication, as its effectiveness could be compromised.
Once the medication has completely dissolved, take a generous sip of water and gently swish it around your teeth and gums before swallowing. This step aids in preventing potential dental issues. Refrain from brushing your teeth for at least an hour after using the medication.
For most patients, buprenorphine alone is typically administered during the initial 2 days following the cessation of all other opioids.
This usually takes place in a medical setting. Subsequently, your doctor will transition you to the combined buprenorphine/naloxone medication for ongoing maintenance treatment.
The combination including naloxone functions similarly to buprenorphine alone in order to stave off withdrawal symptoms. In some cases, this combined product might be employed to initiate treatment (referred to as induction). Precisely adhere to the instructions provided by your doctor.
Dosage adjustments are contingent upon your medical condition and your response to the treatment. It is not advisable to augment the dosage, increase the frequency of intake, or prolong the duration of usage beyond the prescribed period. Terminate the medication as directed.
In order to derive the maximum benefit from this medication, it is imperative to use it consistently. To facilitate remembrance, administer it at the same time each day.
Buprenorphine/naloxone has the potential to induce withdrawal symptoms, particularly if employed shortly after the use of opioids such as heroin, morphine, or methadone. Abide by the treatment plan outlined by your doctor.
Should you abruptly discontinue the usage of this medication, withdrawal symptoms may manifest, including restlessness, teary eyes, a runny nose, nausea, sweating, and muscle discomfort. To mitigate the occurrence of withdrawal, your doctor might opt to gradually lower your dosage.
Withdrawal symptoms are more likely if the medication has been used for an extended period or in high doses. Should withdrawal symptoms arise, promptly inform your doctor or pharmacist.
It is essential to avoid injecting (“shooting up”) buprenorphine/naloxone or inhaling it through the nasal passage (“snorting”).
Such actions are perilous and are likely to lead to severe withdrawal symptoms, mainly due to the presence of naloxone in the medication. This is especially true if you have previously used opioids like heroin, morphine, or methadone. Additional information can be obtained from your doctor or pharmacist.
Possible Side Effects
Encompass drowsiness, dizziness, constipation, or headaches. Should any of these reactions persist or worsen, it is advised to promptly inform your doctor or pharmacist.
To stave off constipation, incorporating dietary fibre into your diet, maintaining adequate hydration, and engaging in physical activity are recommended. In certain cases, a laxative might be necessary. Your pharmacist can guide you in selecting an appropriate laxative.
In order to mitigate the risk of dizziness and a sensation of lightheadedness, exercise caution when transitioning from a seated or reclined position to standing up.
Keep in mind that your doctor has prescribed this medication after evaluating that the benefits outweigh the potential side effects. A significant proportion of individuals using this medication experience no serious adverse effects.
Misusing, injecting, or combining this medication with other depressants like alcohol, benzodiazepines (e.g., diazepam), or other opioids can lead to severe, potentially fatal breathing difficulties.
Notify your doctor immediately if you experience any severe adverse effects, including interrupted breathing during sleep (sleep apnea), alterations in mental state (e.g., restlessness, confusion, hallucinations), stomach or abdominal pain, tooth or gum pain, or signs of compromised adrenal gland function (e.g., unusual fatigue, weight loss).
While this medication is intended to avert withdrawal reactions, it may rarely induce opioid withdrawal symptoms such as diarrhoea, pronounced changes in mood (e.g., anxiety, irritability, sleep disturbances), muscle rigidity, or trembling. This is more likely during initial treatment or if you have been using long-acting opioids like methadone. Should such symptoms arise, promptly notify your doctor or pharmacist.
Precautions
Before initiating the use of this medication, it’s important to disclose to your doctor or pharmacist if you have allergies to buprenorphine or naloxone, or any other allergies. Inactive components within the product could trigger allergic reactions or other complications. Consulting your pharmacist can provide more comprehensive information in this regard.
- Allergies: Inform your doctor or pharmacist if you are allergic to buprenorphine or naloxone, or if you have any other allergies. Inactive ingredients in the medication can potentially trigger allergic reactions or other issues.
- Medical History: Before using this medication, disclose your medical history to your doctor or pharmacist. Especially mention any history of brain disorders (such as head injuries, tumours, or seizures), breathing problems (like asthma, sleep apnea, or chronic obstructive pulmonary disease-COPD), liver disease, mental/mood disorders (including confusion or depression), stomach/intestinal issues (such as blockages, constipation, or infection-related diarrhoea), or difficulties with urination due to an enlarged prostate.
- Dizziness and Drowsiness: This medication might cause dizziness or drowsiness. Avoid activities that require alertness, like driving or operating machinery, until you are confident in your ability to do so safely. Alcohol or marijuana (cannabis) can intensify these effects.
- Heart Rhythm (QT Prolongation): Buprenorphine in the medication could lead to QT prolongation, a condition affecting the heart rhythm. This can result in potentially serious irregular heartbeat and other symptoms like severe dizziness or fainting. Alert your doctor if you have certain heart problems, a family history of heart problems, or if you are taking medications that may cause QT prolongation.
- Electrolyte Imbalance: Low levels of potassium or magnesium in the blood can increase the risk of QT prolongation. Inform your doctor if you have conditions or are taking medications that might lead to electrolyte imbalances, such as diuretics (“water pills”), or if you are experiencing conditions like excessive sweating, diarrhoea, or vomiting.
- Alcohol and Other Depressants: Avoid combining this medication with alcohol, benzodiazepines, or other depressants, as it can lead to severe breathing difficulties.
- Use of Marijuana: If you use marijuana (cannabis), discuss this with your doctor, as it can interact with the medication and amplify certain side effects.
- Liver Function: This medication may rarely cause serious liver disease. Watch out for symptoms such as persistent nausea, vomiting, dark-coloured urine, loss of appetite, yellowing of the eyes or skin, or intense abdominal pain. Seek medical help if such symptoms arise.
- Phenylketonuria (PKU): If you have phenylketonuria (PKU) or any other condition requiring restricted intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this medication safely.
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Interactions with other drugs are a crucial consideration when taking the N8 LOGO Pill.
Here is information about potential drug interactions:
The way your medications function or the risk of serious side effects could be altered due to drug interactions. This document doesn’t encompass all potential interactions.
It’s essential to maintain a record of all products you use, including prescription/nonprescription drugs and herbal products, and share this list with your doctor and pharmacist. Altering the dosage or discontinuing any medications should only be done with your doctor’s consent.
Potential Interacting Products:
- Certain pain medications like mixed opioid agonist-antagonists (such as butorphanol, nalbuphine, and pentazocine).
- Naltrexone.
- Samidorphan.
The likelihood of severe side effects (like slow or shallow breathing, profound drowsiness, or intense dizziness) could increase if this medication is used alongside other products that also impact breathing or induce drowsiness.
Inform your doctor or pharmacist if you are taking other substances like alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), medications for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and other opioid pain relievers (like codeine, hydrocodone).
Conclusion
The N8 LOGO Pill, identified as an orange, six-sided pill measuring 11mm, contains a combination of buprenorphine and naloxone.
This medication is primarily used for the treatment of Opioid Use Disorder. It’s important to adhere closely to your doctor’s instructions and the provided Medication Guide to ensure safe and effective usage.
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